Kühn Lab
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Research
Rapid mRNA degradation and mice with conditional ferritin H deletion
About 5 percent of all human genes produce mRNA that is unstable. We study how specific sequences in unstable mRNAs are recognized by nuclear and cytoplasmic proteins and how this initiates rapid mRNA degradation. We have notably studied IL‑6, c‑myc and cyclin mRNAs. We also have constructed a mouse strain to learn about physiological consequences of a conditional deletion of the ferritin H gene. Ferritin stores iron and protects cells from the formation of hydroxyl radicals, potentially oncogenic compounds that modify nucleotides in DNA.
Our main research topics
Conditional knock-out mice for ferritin H
Oxydative cell damage, iron physiology
mRNA degradation, RNA protein interactions
Laboratory of Prof. Lukas Kühn
SV 2516 (Bâtiment SV)
Station 19
CH-1015 Lausanne
Secretariat
Mme Geneviève Massy
Phone +4121 693 0992
Prof. L. Kühn
Phone +4121 693 0746